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What is our focus?

We use epigenetics, genomics and bioinformatics to answer fundamental scientific questions and reveal key factors and new mechanisms in the regulation of cellular homeostasis. Particular emphasis is placed on the regulatory functions and interactions of epigenetically regulated factors with medical diagnostic and therapeutic applications. At the same time, we are advancing our understanding of genomic evolution and cell-environment interactions.

What materials do we use for research?

Protozoan ciliates (e.g. Tetrahymena, Paramecium, Euplotes).

Collaborative studies: mammals (humans, mice, etc.).

Why do we use protozoan ciliates for research?

As excellent model organisms, protozoan ciliates (e.g. Tetrahymena) offer distinct advantages in epigenetics research:

1) They are the most complex single-celled organisms with rich phenotypes, facilitating observation;

2) Established culture systems enable rapid cell expansion for experiments, ensuring high efficiency and low cost;

3) Nuclear dimorphism (identical gene sequences in macronuclei and micronuclei, but distinct chromatin environments) allows mutual control;

4) They have well-defined genetic backgrounds (e.g. genome), and there are mature genomic manipulation techniques available;

5) Their histone modification sites and epigenetic factors are highly conserved with those of higher organisms, enabling regulatory mechanisms discovered to be extrapolated to mammals.