2025年

1、Shi, C.; Liu, R.; Wang, Z.; Gao, C.; Chen, J.-S.; Qin, H.; Shan, W.; Zhuang, W.; Zhou, N.; Li, X.; Shi, D. Anaerobic 1,2-/1,3-Hydroxytrifluoromethylation of Unactivated Alkenes Enabled by Photoexcited Nitroarenes. Organic Letters 2025, 27, 922-926.

 

 2、Gao, C.; Hu, W.; Xu, F.; Lin, Y.; Chen, J.; Shi, D.; Xing, P.; Zhu, J.; Li, X. Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives. European Journal of Medicinal Chemistry 2025, 282, 117053.

 

2024年

1、Qin, H. Y.; Liu, R. H.; Wang, Z. M.; Xu, F.; Li, X. W.; Shi, C.; Chen, J. S.; Shan, W. L.; Liu, C.; Xing, P.; Zhu, J. Q.; Li, X. Q.; Shi, D. Y. Photoinduced Bartoli Indole Synthesis by the Oxidative Cleavage of Alkenes with Nitro(hetero)arenes. Angewandte Chemie International Edition 2024, e202416923.

 

2、Li, X.; Shan, W.; Zhou, N.; Wang, Z.; Liu, R.; Zhuang, W.; Yuan, L.; Shi, C.; Qin, H.; Chen, J.; Li, X.; Shi, D. Nickel-Catalyzed Stereoconvergent C(sp2)–F Alkenylation of Monofluoroalkenes. Organic Letters 2024, 26, 8521-8526.

 

 3、Yuan, L.; Wang, Z.; Zhuang, W.; Li, X.; Shi, C.; Li, X.; Shi, D. Visible-Light-Driven Iron-Catalyzed 1,2-Difluoroalkylthiolation of Alkenes. Organic Letters 2024, 26, 7066-7071.

 

 

4、Shan, W.; Wang, Z.; Gao, C.; Li, X.; Zhuang, W.; Liu, R.; Shi, C.; Qin, H.; Li, X.; Shi, D. Visible light-induced cobalt-catalyzed 1,3-diphosphination of alkenes. Green Chemistry 2024, 26, 9749-9756.

 

5、Zhang, Y.; Li, X.; Liu, F.; Bai, X.; Liu, X.; Sun, H.; Gao, C.; Lin, Y.; Xing, P.; Zhu, J.; Liu, R.; Wang, Z.; Dai, J.; Shi, D. Design of Selective PARP-1 Inhibitors and Antitumor Studies. Journal of Medicinal Chemistry 2024, 67, 8877-8901.

 

6、Shi, C.; Liu, R.; Wang, Z.; Li, X.; Qin, H.; Yuan, L.; Shan, W.; Zhuang, W.; Li, X.; Shi, D. Radical Addition-Enabled C–C σ-Bond Cleavage/Reconstruction to Access Functional Indanones: Total Synthesis of Carexane L. Organic Letters 2024, 26, 2913-2917.

 

 7、Wang, Z.; Yan, C.-X.; Liu, R.; Li, X.; Dai, J.; Li, X.; Shi, D. Photo-induced versatile aliphatic C–H functionalization via electron donor–acceptor complex. Science Bulletin 2024, 69, 345-353.

2023年

1.Xiaowei Li, Yuxiu Li, Zemin Wang, Wenlong Shan, Ruihua Liu, Cong Shi, Hongyun Qin, Leifeng Yuan, Xiangqian Li, and Dayong Shi*.Nickel-Catalyzed Stereoselective Cascade C−F Functionalizations of gem-Difluoroalkenes. ACS Catal. 2023, 13, 2135−2141

2.Xiaowei Li, Yuxiu Li,Wenlong Shan, Zemin Wang, Ruihua Liu,Zhong Zhang, Xiangqian Li and Dayong Shi *.Nickel-catalyzed stereoselective reductive cross-coupling of gem-difluoroalkenes with alkenyl electrophiles.Chem. Commun., 2023, 59, 6893

3.Zhong Zhang, Yang Tian, Xiaowei Li, Zemin Wang, Ruihua Liu, Ping Chen, Xiangqian Li, Jiajia Dai and Dayong Shi*.S-Trifluoromethyl thioesters as bifunctional reagents for acyl-trifluoromethylthiolation of alkenes and 1,3-enynes via photoredox/copper dual catalysis.Green Chem., 2023, 25, 2723–2729

4.Xueju Qi, Jing Wang, Fengshu Fei, Xintao Gao, Xiaochen Wu, Dayong Shi,* and Chuanlong Guo*Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS−STING Signaling Pathway.Mol. Pharmaceutics 2023, 20, 136−146

5.Kehong Dong, Mei Zhang, Ying Liu, Xintao Gao, Xiaochen Wu, Dayong Shi,* Chuanlong Guo,*and Jing Wang*.Pterostilbene-Loaded Soluplus/Poloxamer 188 Mixed Micelles for Protection against Acetaminophen-Induced Acute Liver Injury.Mol. Pharmaceutics 2023, 20, 1189−1201.

6.Shuo Li# , Jia-shu Chen# , Xiangqian Li, Xiaoyi bai, Dayong Shi *.MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation.European Journal of Medicinal Chemistry 260 (2023) 115781

7.Fang Liu#, Jiashu Chen# , Xiangqian Li, Ruihua Liu, Yiting Zhang, Chenxia Gao, Dayong Shi *Advances in Development of Selective Antitumor Inhibitors That Target PARP-1.J. Med. Chem. 2023, 66, 16464−16483

8.Ting Shi, Yan-Jing Li , Ze-Min Wang, Yi-Fei Wang, Bo Wang * and Da-Yong Shi *New Pyrroline Isolated from Antarctic Krill-Derived Actinomycetes Nocardiopsis sp. LX-1 Combining with Molecular Networking .Mar. Drugs 2023, 21, 127.

2022年

1.Yan-yan Yu #, Xiang-qian Li #, Wen-peng Hu , Shi-chao Cu , Jia-jia Dai , Ya-nan Gao , Yi-ting Zhang , Xiao-yi Bai , Da-yong Shi *.Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation, Biomedicine & Pharmacotherapy 2022,147 :112615

2.Jiajia Dai , Yiting Zhang , Yanan Gao , Xiaoyi Bai , Fang Liu , Shuo Li , Yanyan Yu , Wenpeng Hu ,Ting Shi , Dayong Shi * and Xiangqian Li*.Toward a treatment of cancer: design and in vitro/in vivo evaluation of uncharged pyrazoline derivatives as a series of novel SHP2 inhibitors, Int. J. Mol. Sci. 2022, 23:3497

3.Ting Shi, Xiang-Qian Li , Ze-Min Wang ,Li Zheng, Yan-Yan Yu , Jia-Jia Dai and Da-Yong Shi *.Bioactivity-Guided Screening of Antimicrobial SecondaryMetabolites from Antarctic Cultivable Fungus Acrostalagmusluteoalbus CH-6 Combined with Molecular Networking，Mar. Drugs ,2022, 20, 334.

4.Ruihua Liu , Yang Tian, Jie Wang, Zemin Wang, Xiangqian Li, Chenyang Zhao, Ruoyu Yao, Shuo Li, Leifeng Yuan, Jinbo Yang*, Dayong Shi*.Visible light–initiated radical 1,3-difunctionalization of β,γ-unsaturated ketones. Sci. Adv.2022, 8, 49, eabq8596

2021年

1.Xiaolin Shi, Zemin Wang, Yuxiu Li, Xiaowei Li, Xiangqian Li, and Dayong Shi*,Palladium-Catalyzed Remote C-H Phosphonylation of Indoles at the C4 and C6 Positions by a Radical Approach, Angew. Chem. Int. Ed. 2021, 60, 13990–13995 

2.Yuxiu Li, Xiangqian Li, Xiaowei Li and Dayong Shi*,Visible-light-promoted E-selective synthesisof a-fluoro-b-arylalkenyl sulfides via the deoxygenation/isomerization process, Chem. Commun., 2021, 57, 2152-2155

3.Yuxiu Li, Xiangqian Li, Xiaowei Li, and Dayong Shi*,Highly E‑Selective Synthesis of α‑Fluoro β-arylalkenyl Sulfones from gem-Difluoroalkenes with Sodium Sulfinates，J. Org. Chem. 2021, 86, 6983−6993

4.Zhong Zhang, Xiangqian Li, and Dayong Shi*,Visible-Light-Promoted Oxy-difluoroalkylation of Aryl Alkynes for the Synthesis of β-Fluoroenones and α-Difluoroalkyl Ketones， Adv. Synth. Catal. 2021, 363, 3348-3353

5.Ting Shi , Yan-Yan Yu , Jia-Jia Dai , Yi-Ting Zhang , Wen-Peng Hu , Li Zheng* and Da-Yong Shi *,New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11, Mar. Drugs 2021, 19, 168.

6.Ting Shi , Li Zheng, Xiang-Qian Li, Jia-Jia Dai , Yi-Ting Zhang , Yan-Yan Yu , Wen-Peng Hu and Da-Yong Shi * Nitrogenous Compounds from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11, Molecules 2021, 26, 2636.

7.Ting Shi, Xiang-Qian Li, Li Zheng, Ya-Hui Zhang, Jia-Jia Dai, Er-Lei Shang, Yan-Yan Yu, Yi-Ting Zhang, Wen-Peng Hu, Da-Yong Shi* Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11, Front. Microbiol. 2021，12：688202 (IF= 5.640)

8.Xiangqian Li, Xiaowei Li, Fang Liu, Shuo Li, and Dayong Shi*，Rational Multitargeted Drug Design Strategy from the Perspective of a Medicinal Chemist，J. Med. Chem. 2021, 64, 15, 10581–10605 

9.Xiaowei Li#, Yuxiu Li#, Zhong Zhang, Xiaolin Shi, Ruihua Liu, Zemin Wang, Xiangqian Li, Dayong Shi*, Nickel-Catalyzed Arylation of C(sp 3)-O Bonds in Allylic Alkyl Ethers with Organoboron Compounds. Org. Lett. 2021, 23, 17, 6612–6616 

10.Ping Chen, Wei Cao, Xiangqian Li, and Dayong Shi* A Unified Approach for Divergent Synthesis of Heterocycles via TMSOTf-Catalyzed Formal [3+2] Cycloaddition of Electron Rich Alkynes. Adv. Synth. Catal. 2021，363，4789-4794

11.Jiajia Zhang, Ning Wu* and Dayong Shi*,The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review. Mini-Reviews in Medicinal Chemistry, 2021, 21, 803-815

2020年

1、Jiajia Zhang , Jiajia Dai, Qingxuan Zheng, Shuju Guo, Yanyan Yu, Wenpeng Hu, Yanan Gao and Dayong Shi * The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction，Int. J. Mol. Sci. 2020, 21, 1038-1053

2、Haonan Zhang, Zhengquan Gao, Chunxiao Meng*, Xiangqian Li* and Dayong Shi*. Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2. Mini-Rev Med Chem. 2020, 21, 1038-1053

3、Jiao Luo, Yufei Hou, Mengyue Xie, Wanli Ma, Dayong Shi * and Bo Jiang *. CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes. Mar. Drugs. 2020, 18, 267-280

4、Chuanlong Guo*, Fan Zhang, Xiaochen Wu, Xuemin Yu, Xianggen Wu, Dayong Shi*, Lijun Wang*.BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo. Int. J. Biol. Macromol. 2020,150,238-245（IF= 6.953）

5、Xiuxue Li, Lijun Wang, Xiaoling Jia, Chuanlong Guo, Chao Li, Jiajia Zhang and Dayong Shi*An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study. Journal of Analytical Science and Technology. 2020;11(1):1-7

6、Liang Zhang#, Jiao Luo #, Xiangqian Li , Shuju Guo * and Dayong Shi*. 16S rRNA sequencing and metagenomics study of gut microbiota: implications of BDB on type 2 .Mar. Drugs. 2020, 18, 469-486

7、Xiaowei Li, Yuxiu Li, Ruihua Liu, Zemin Wang, Xiangqian Li, Dayong Shi*. AcOH-mediated aerobic oxidative synthesis of 2-thioalkylbenzothiazoles via a three-component reaction. Tetrahedron Letters. 2020,61(26) ,152054

8、Jiao Luo, Meiling Zheng, Bo Jiang, Chao Li, Shuju Guo, Lijun Wang, Xiangqian Li, Rilei Yu, Dayong Shi*. Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides. Br J Pharmacol. 2020; 177(19):4464-4480 

2019年

1、Chuanlong Guo, Lijun Wang,* Xiuxue Li, Shuaiyu Wang, Xuemin Yu,Kuo Xu, Yue Zhao, Jiao Luo, Xiangqian Li, Bo Jiang, and Dayong Shi* Discovery of  Novel Bromophenol−Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase‑1 (PARP-1) for Use in Cancer. J. Med. Chem. 2019, 62, 3051−3067

2、Chao Li, Jiao Luo, Shuju Guo, Xiaoling Jia, Chuanlong Guo, Xiangqian Li,Qi Xu, and Dayong Shi*Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2′,3,3′- Tetrabromo-4,4′,5,5′-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice. Mol. Pharmaceutics. 2019, 16, 1839-1850

3、Xiaolin Shi, Xiaowei Li , Lina Ma and Dayong Shi *.Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base. Catalysts. 2019, 9, 278

4、Hua Liu #, Chuanlong Guo# , Shuju Guo , Lijun Wang* and Dayong Shi *Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells. Molecules. 2019, 24, 375

5、Xiangqian Li, Qi Xu, Chao Li , Jiao Luo, Xiuxue Li , Lijun Wang , Bo Jiang，Dayong Shi  *Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors. European Journal of Medicinal Chemistry. 2019,166,178-185

6、Kuo Xu, Chuanlong Guo , Jie Meng , Haiying Tian , Shuju Guo *and Dayong Shi * Discovery of natural dimeric naphthopyrones as potential cytotoxic agents through ROS-mediated apoptotic pathway. Mar. Drugs. 2019, 17, 207

7、Qi Xu, Ning Wu, Xiangqian Li, Chuanlong Guo, Chao Li, Bo Jiang, Huaizhi Wang and Dayong Shi*Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway. Cell Death and Disease. 2019,10:874

8、Lijun Wang *, Chuanlong Guo , Xiuxue Li , Xuemin Yu , Xiangqian Li ,Kuo Xu, Bo Jiang , Xiaoling Jia , Chao Li , Dayong Shi *Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment. European Journal of Medicinal Chemistry. 2019, 177,153-170

9、Hua Liu, Chuanlong Guo, Shuju Guo, Junting Fan, Lijun Wang*,Dayong Shi *Chalcone-analogue fluorescent probes for detecting thiophenols in seawater  samples. Talanta. 2019, 201, 301–308

10、Chuanlong Guo , Lijun Wang ,Yue Zhao,Bo Jiang, Jiao Luo, Dayong Shi* . BOS‑93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway. Experimental and therapeutic medicine.2019, 17(5): 3848–3858

11、Chuanlong Guo, Lijun Wang, Xiuxue Li, Shuaiyu Wang, Xuemin Yu, Kuo Xu, Yue Zhao, Jiao Luo, Xiangqian Li, Bo Jiang, and Dayong Shi* Chalcone-analogue fluorescent probes for detecting thiophenols in seawater samples. Talanta.2019, 62, 3051-3067

12、Xiaowei Li , Xiaolin Shi, Xiangqian Li, Dayong Shi*. Recent advances in transition-metal-catalyzed incorporation of fluorine-containing groups. Beilstein J Org Chem. 2019; 15: 2213–2270. 

13、Jiao Luo#, Bo Jiang#, Chao Li, Xiaoling Jia and Dayong Shi*CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs. Mar. Drugs. 2019, 17(1), 49. 

14、Xiaolin Shi, Xiaowei Li, Xiangqian Li* and Dayong Shi*Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions. Front. Chem. 2019; 7: 613. 

15、Chao Li, Dayong Shi*.Structural and Bioactive Studies of Halogenated Constituents from Sponges .Current Medicinal Chemistry, 2019, 26, 1-26 .

16、Yuanyuan Zhang, Junhong Liu*, Dayong Shi* and Zheng Li. Halogenated Compounds from Corals: Chemical Diversity and Biological Activities, Mini-Reviews in Medicinal Chemistry, 2019, 19, 1204-1218.

1. 史大永；王泽敏；戴佳佳；一种环烷基丙烯酸酯化合物的合成方法，2024-5-10中国，ZL202211299872.3

2. 史大永,田阳,刘瑞华,朱继强. 一种异硫氰酸酯的合成方法，2024-03-01.中国, ZL202211452966.X

3. 田阳,史大永,刘瑞华,朱继强. 一种硫代氟甲酸酰胺的合成方法，2024-04-12.中国, ZL202211549448.X

4. 史大永,刘瑞华,李祥乾,田阳,赵晨阳. β-双磺酰亚胺取代酮类化合物在治疗癌症中的应用， 中国, 2024-01-23.ZL202110987570.4

5. 史大永,李祥乾,王鑫,许凤. 溴酚-吡唑啉化合物在治疗猫冠状病毒疾病中的应用,中国,  2024-03-26，ZL 202111190625.5

6. 史大永,李祥乾,王鑫,许凤. 溴酚-吡唑啉化合物在治疗禽冠状病毒疾病中的应用,2024-03-26.中国, ZL202111190708.4

7. Dayong Shi;Xiangqian Li;XinWang;Feng Xu;Use of Bromophenol pyrazoline Compounds in the Treatment of Feline Infectious Peritonits.2024-5-8，欧洲，EP4166138B1

8. Dayong Shi;Xiangqian Li;XinWang;Feng Xu;Use of Bromophenol-Pyrazoline Compounds for the Treatment of Feline Coronavirus Diseases.2023-12-12，美国，US 11,840,518 B2

9. Dayong Shi;Xiangqian Li; XinWang; Jinbo Yang; Feng Xu; Rong Zhang;Use of Bromophenol-Pyrazoline Compounds in the Treatment of Porcine Coronavirus Diseases. 2023-9-12，美国，US 11,752,133 B2

10. Dayong Shi;Xiangqian Li;XinWang;Jinbo Yang;Bromophenol-Pyrazoline Compound and Synthesis method and use thereof. 2023-11-21，美国，US11,820,763 B2

11. 史大永;张众;李祥乾;一种氟代烯基酮类化合物的制备方法，2022-11-15，中国，ZL202110040909.X

12. 史大永;史晓琳;李祥乾;一种4-膦酸烷基酯取代吲哚化合物的合成方法，2022-11-22，中国，ZL202110066149.X

13. 史大永;李晓伟;许凤;一种烯丙基芳基类化合物的合成方法，2022-11-01，中国，ZL202110206297.7

14. 史大永;王泽敏;一种烷基硫代磺酸酯化合物的合成方法，2022-09-20，中国，ZL202110334490.9

15. 史大永;王泽敏;一种烷基硫醚化合物的合成方法，2022-09-23，中国，ZL202110335420.5

16. 史大永;许凤;田阳;一种邻苯二甲酰亚胺型三氟甲硫化试剂的合成方法，2022-08-26，中国，ZL202110209605.1

17. 史大永;田阳;许凤;一种三氟甲烷硫醇银(I)的合成方法，2022-08-19，中国，ZL202110211672.7

18. 史大永;田阳;许凤;刘瑞华;一种丁二酰亚胺型三氟甲硫化试剂的合成方法，2022-08-23，中国，ZL202110214011.X

19. 史大永；李祥乾；王鑫；杨金波；溴酚-吡唑啉类化合物及其合成方法和应用，2022-4-1，中国，ZL202010773200.6

20. 史大永；李祥乾；王鑫；杨金波；许凤；张荣；溴酚-吡唑啉类化合物在治疗猪冠状病毒疾病中的应用，2022-2-18，中国，ZL202011506016.1

21. 史大永; 田阳; 刘瑞华; 李祥乾；一种三氟甲硫酯类化合物的合成方法, 2021-8-31, 中国, ZL202011200750.5

22. 史大永；刘华；郭传龙；王立军；郭书举；江波；查尔酮类荧光探针在检测水溶液中苯硫酚类化合物的应用，2021-7-27，中国，ZL201811352560.8

23. 史大永; 郭传龙; 王立军; 赵越; 江波; 李祥乾 ; 一种哌啶-溴酚-吲哚酮杂合体化合物在抗肿瘤药物中的应用, 2020-6-19, 中国, ZL201710304762.4

24. 史大永; 郭传龙; 王立军; 江波; 李祥乾 ; 三醛基间苯三酚缩氨基硫脲杂合体化合物在抗肿瘤药物中的应用, 2020-5-15, 中国, ZL201810753795.1

25. 史大永; 王立军; 郭传龙; 李祥乾; 江波; 李晓伟 ; 六种PARP1抑制剂的制备及其应用, 2020-4-24,中国, ZL201810812259.4

26. 史大永；李祥乾；王立军；江波；吴宁；海藻胶植物性软胶囊囊壳及制备方法，2020-3-10，中国，ZL201611150751.7

27. 史大永; 李祥乾; 王立军; 江波 ; 噁二唑类化合物及其在制备预防和/或治疗2型糖尿病药物中的应用, 2019-7-26, 中国, ZL201611175726.4

28. 史大永；王立军；江波；吴宁；王帅玉；一类LSD1抑制剂及其应用，2019-6-25，中国，ZL201410180766.2

29. 史大永; 王帅玉; 王立军; 江波; 吴宁 ; 一种化合物在制备RTKI和/或抗血管生成药物中应用, 2019-2-26, 中国, ZL201410471853.3

30. 史大永；王立军；郭传龙；江波；王帅玉；赵越；一类新型溴酚氨基硫脲类化合物及其制备和药物与用途，2018-11-13，中国，ZL201611069927.6

31. 史大永；江波；王立军；吴宁；王帅玉；李祥乾；杨猛；九种PTP1B抑制剂及其合成和有应用，2018-4-17，中国，ZL201510278442.7

32. 史大永; 王保程; 王立军; 江波 ; 一种氟代PTP1B抑制剂及其合成和应用, 2018-1-9, 中国, ZL201610202143.X

33. 史大永; 郭书举; 范晓; 路伟申; 崔永超 ; PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for treating type 2 diabetes mellitus, 2014-8-26, 美国, US8816129 B2

34. 史大永；李超；韩丽君；郭书举；袁毅；溴代PTP1B抑制剂及其合成和在制备糖尿病药物中的应用，2013-1-2，中国，ZL200810016802.6

35. 史大永；范晓；卢伟伸；郭书举；崔永超；一类治疗血栓性心脑血管2013-3-27，中国，ZL201010147850.6

36. 史大永；郭书举；李敬；抗2型糖尿病药物“海普诺”的化学全合成方法，2013-4-17，中国，ZL200910017839.5

37. 史大永；范晓；李敬；郭书举；PTP1B抑制剂及其制备和在制备治疗2型糖尿病药物中的应用，2013-7-24，中国，ZL201010147875.6

38. 史大永；范晓；李敬；郭书举；一种PTP1B抑制剂及其合成和应用，2014-4-16，中国，ZL201010147883.0

39. 史大永；范晓；李敬；郭书举；PTP1B抑制剂及其合成和在制备2型糖尿病药物中的应用，2012-7-25，中国，ZL201010147904.9

40. 史大永；范晓；李敬；郭书举；PTP1B抑制剂及其合成和应用，2012-9-12，中国，ZL201010147905.3

41. 史大永；范晓；李敬；郭书举；PTP1B抑制剂及其合成与应用，2012-9-12，中国，ZL201010147902.X

42. 史大永；范晓；李敬；郭书举；一种PTP1B抑制剂及其合成和在制备治疗2型糖尿病药物中的应用，2012-9-12，中国，ZL201010147874.1

43. 史大永；范晓；李敬；郭书举；一种PTP1B抑制剂及其化学合成方法和应用，2012-9-19，中国，ZL201010147901.5

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